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L4634

Sigma-Aldrich

Leu-Leu acetate salt

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About This Item

Fórmula empírica (notación de Hill):
C12H24N2O3 · C2H4O2
Número de CAS:
73237-76-0
Peso molecular:
304.38
MDL number:
MFCD00069974
UNSPSC Code:
12352202
PubChem Substance ID:
329817412

form

powder

color

white

storage temp.

−20°C

SMILES string

CC(O)=O.CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C12H24N2O3.C2H4O2/c1-7(2)5-9(13)11(15)14-10(12(16)17)6-8(3)4;1-2(3)4/h7-10H,5-6,13H2,1-4H3,(H,14,15)(H,16,17);1H3,(H,3,4)/t9-,10-;/m0./s1

InChI key

JEUHGRPWUPRNDP-IYPAPVHQSA-N

Amino Acid Sequence

Leu-Leu

Biochem/physiol Actions

Leucylleucine (Leu-Leu) may be used to study the functionality of dileucine motifs such as the motif responsible for internalization and targeting of vesicular acetylcholine transporter and clathrin adaptors AP-1 and AP-2. Leucylleucine may be used to study growth supplement requirements in vitro.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A van Boven et al.
Biochimie, 70(4), 535-542 (1988-04-01)
Different strains of Lactococcus lactis ssp. cremoris hydrolyze peptides at different rates while the cell-free extracts of these strains all show the same or much higher rates of hydrolysis. These observations indicate that the uptake of peptides is the rate-limiting
M Plauth et al.
Clinical science (London, England : 1979), 82(3), 283-290 (1992-03-01)
1. We assessed the efficacy of nitrogen absorption from luminal L-leucine (1.2 and 12 mmol/l) and from isonitrogenous L-leucyl-L-leucine (0.6 and 6.0 mmol/l) in a preparation of vascularly and luminally perfused rat small intestine by measuring luminal leucyl-leucine disappearance and
Pedro A Aredes Fernández et al.
Current microbiology, 49(5), 361-365 (2004-10-16)
Oenococcus oeni has numerous amino acid requirements for growth and dipeptides could be important for its nutrition. In this paper the individual or combined effect of dipeptides on growth of O. oeni X2L in synthetic media deficient in one or
O Valdenaire et al.
Journal of cell science, 112 Pt 18, 3115-3125 (1999-08-27)
Endothelin-converting enzyme (ECE-1) is a type II integral membrane protein which plays a key role in the biosynthetic pathway of the vasoconstricting endothelins. Three ECE-1 isoforms, differing by their N-terminal cytoplasmic tails, are generated from a single gene. When expressed
Balraj Doray et al.
Molecular biology of the cell, 18(5), 1887-1896 (2007-03-16)
The clathrin adaptors AP-1 and AP-2 bind cargo proteins via two types of motifs: tyrosine-based Yxx phi and dileucine-based [DE]XXXL[LI]. Although it is well established that Yxx phi motifs bind to the mu subunits of AP-1 or AP-2, dileucine motifs
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