Saltar al contenido
MilliporeSigma
Todas las fotos(1)

Documentos

J2455

Sigma-Aldrich

JNK1, active, GST tagged from mouse

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

JNK, JNK1A1, JNK21B1/2, PRKM8, SAPK1

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

92-124 nmol/min·mg

mol wt

~71 kDa

UniProt accession no.

Q91Y86

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Mapk8(26419)

Biochem/physiol Actions

As a member of the MAP kinase family, JNK1 is known to play a role in the induction of apoptosis through various stimuli such as TNFa.JNK1 also is influences cell migration via phosphorylation of paxillin.JNK1 is also a crucial mediator of obesity and insulin resistance and a potential target for therapeutics.
JNK1 (c-Jun N-terminal kinase 1) is a member of the MAPK (mitogen activated protein kinase) family that controls gene expression by phosphorylation of transcription factors. It is linked with apoptosis, brain development and learning ability. JNK1 also influences cell migration via phosphorylation of paxillin. JNK1 also regulates obesity and insulin resistance.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Hélène Henrie et al.
The Journal of cell biology, 219(7) (2020-06-04)
The stress-induced c-Jun N-terminal kinase (JNK) controls microtubule dynamics by enhancing both microtubule growth and rescues. Here, we show that upon cell stress, JNK directly phosphorylates the microtubule rescue factor CLIP-170 in its microtubule-binding domain to increase its rescue-promoting activity.
Prescott T Leach et al.
Neurobiology of learning and memory, 118, 162-166 (2014-12-30)
Increased training often results in stronger memories but the neural changes responsible for these stronger memories are poorly understood. It is proposed here that higher levels of training that result in stronger memories recruit additional cell signaling cascades. This study
Cai Huang et al.
Nature, 424(6945), 219-223 (2003-07-11)
The c-Jun amino-terminal kinase (JNK) is generally thought to be involved in inflammation, proliferation and apoptosis. Accordingly, its substrates are transcription factors and anti-apoptotic proteins. However, JNK has also been shown to be required for Drosophila dorsal closure, and MAP
C Tournier et al.
Science (New York, N.Y.), 288(5467), 870-874 (2000-05-08)
The c-Jun NH2-terminal kinase (JNK) is activated when cells are exposed to ultraviolet (UV) radiation. However, the functional consequence of JNK activation in UV-irradiated cells has not been established. It is shown here that JNK is required for UV-induced apoptosis
Jiro Hirosumi et al.
Nature, 420(6913), 333-336 (2002-11-26)
Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly understood. The c-Jun amino-terminal kinases (JNKs) can interfere with insulin action in cultured
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico