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F0290000

Flutrimazole

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole

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About This Item

Fórmula empírica (notación de Hill):
C22H16F2N2
Número de CAS:
119006-77-8
Peso molecular:
346.37
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

flutrimazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H

InChI key

QHMWCHQXCUNUAK-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Flutrimazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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D Rigopoulos et al.
Mycoses, 50(3), 193-195 (2007-05-03)
Flutrimazole is an imidazole derivative that has been proven to be efficient in superficial skin fungal infections. The aim of this randomised double-blind study was to compare for the first time, the efficiency and safety of flutrimazole 1% shampoo versus
[Facial dermatophytide reaction].
B Monteagudo Sánchez et al.
Anales de pediatria (Barcelona, Spain : 2003), 68(4), 411-412 (2008-04-09)
A del Palacio et al.
Mycoses, 43(9-10), 355-365 (2000-12-06)
A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal candidosis. Vaginitis was demonstrated by both positive findings on microscopic examination of
B John et al.
Arzneimittel-Forschung, 48(5), 512-517 (1998-06-25)
In order to improve the effectiveness of treatment of vaginal yeast infections, flutrimazole, (CAS 119006-77-8), a broad spectrum local imidazolic fungicide, has been formulated in an advanced delivery system (Site Release, here in after briefly referred to as SR) designed
M Merlos et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 45(1), 20-25 (1996-01-01)
The topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal, have been evaluated. Flutrimazole inhibited mouse ear oedema induced by arachidonic acid, tetradecanoylphorbol-acetate and dithranol, with IC50 values of 3.32, 0.55 and 2.42 mumols/ear, respectively. Ketoconazole showed similar potency in
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