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Documentos clave

05-572

Sigma-Aldrich

Anti-Caspase 9 Antibody, clone 96-2-22

clone 96-2-22, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

96-2-22, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_032996

UniProt accession no.

P55211

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... CASP9(842)

Specificity

Recognizes the proform and the active cleaved form of Caspase 9.

Immunogen

The N-terminal fragment of human Caspase 9 (amino acid residues 1-134)

Application

This Anti-Caspase 9 Antibody, clone 96-2-22 is validated for use in WB for the detection of Caspase 9.

Quality

routinely evaluated by immunoblot on RIPA lysates from A431, Raji, or HFF cells

Target description

46/34 kDa

Linkage

Replaces: 04-443

Physical form

Format: Purified
Protein A Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

Analysis Note

Control
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for minigels.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Giuseppe Filomeni et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17(1), 64-66 (2002-11-09)
Changes in the intracellular reduced/oxidized glutathione ratio (GSH/GSSG) are crucial reduction-oxidation (redox) events that trigger downstream proliferation or death responses. We investigated the molecular mechanisms underlying redox-mediated cell signaling upon an oxidative insult by treating U937 cells with exogenous nonpermeable
J Rodriguez et al.
Genes & development, 13(24), 3179-3184 (2000-01-05)
Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of apoptosis. Activation of caspase-9, which mediates oncogene and drug-induced apoptosis, requires binding to the protein APAF-1. We found that the proteolytic activity of caspase-9
BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-induced Apoptosis.
Wicker CA, Sahu RP, Kulkarni-Datar K, Srivastava SK, Brown TL
Cancer growth and metastasis null
Cell cycle arrest and proapoptotic effects of the anticancer cyclodepsipeptide serratamolide (AT514) are independent of p53 status in breast cancer cells.
Vanessa Soto-Cerrato, Beatriz Montaner, Marc Martinell, Marta Vilaseca, Ernest Giralt et al.
Biochemical Pharmacology null
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Liu, C; Erlichman, C; McDonald, CJ; Ingle, JN; Zollman, P; Iankov, I; Russell, SJ; Galanis, E
Gene Therapy null
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