RB1
retinoblastoma 1
Sinónimos:
OSRC, RB, p105-Rb, pRb, pp110
Especie:
Human RB1 (5925), Mouse Rb1 (19645), Rat Rb1 (24708), chicken RB1 (386582), Zebrafish rb1 (777733), domestic cat RB1 (101101356), dog RB1 (476915), cow RB1 (534712), Horse RB1 (100057080), sheep RB1 (100144755) ...Más
ID UniProtKB:
ID del gen:
- Human(5925) Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- Mouse(19645) retinoblastoma 1
- Rat(24708) retinoblastoma 1
- chicken(386582) retinoblastoma 1
- Zebrafish(777733) retinoblastoma 1
- domestic cat(101101356) retinoblastoma 1
- dog(476915) retinoblastoma 1
- cow(534712) retinoblastoma 1
- Horse(100057080) retinoblastoma 1
- sheep(100144755) retinoblastoma 1
- Domestic Rabbit(100357431) retinoblastoma 1
- domestic guinea pig(100716297) retinoblastoma 1
- naked mole-rat(101703701) retinoblastoma 1
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Rb Antibody, clone 2M15 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-Retinoblastoma, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Anti-phospho-Retinoblastoma (pSer608) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
immunohistochemistry
western blot
western blot
Anti-Phospho-Rb-S807/811 antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
western blot
Anti-RB antibody produced in rabbit, ,
Reactividad de especies
human, rat
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Kits
Referencia del producto
Descripción
Especie
CpG WIZ™ RB1 - Methylation specific PCR assay, MSP, performed using the CpGenome DNA Modification Kit & the CpG WIZ RB1 Amplification Kit, permits sensitive detection of altered DNA.,
Especie
human
Proteins
Referencia del producto
Descripción
Especie
Retinoblastoma Protein (aa 773-928), Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.,
Especie
human
Retinoblastoma protein human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Especie
human