Saltar al contenido
MilliporeSigma

GCK

glucokinase (hexokinase 4)

Sinónimos:
FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Especie:
ID UniProtKB:
ID del gen:
  • Human(2645) Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
  • Mouse(103988) glucokinase
  • Rat(24385) glucokinase
  • Zebrafish(751668) glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
  • chicken(430370) glucokinase (hexokinase 4)
  • domestic cat(100037406) glucokinase (hexokinase 4)
  • dog(606490) glucokinase (hexokinase 4)
  • sheep(101117412) glucokinase (hexokinase 4)
  • cow(616576) glucokinase (hexokinase 4)
  • Horse(100051836) glucokinase (hexokinase 4)
  • naked mole-rat(101721664) glucokinase (hexokinase 4)
  • domestic guinea pig(100717630) glucokinase (hexokinase 4)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-GCK antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
Anti-Glucokinase/GCK Antibody, clone 9G1.2, clone 9G1.2, from mouse,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
Anti-Glucokinase (GCK) Antibody, clone 4K9D5, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunoprecipitation (IP)
western blot
Monoclonal Anti-GCK, (C-terminal) antibody produced in mouse, clone 1G10, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
western blot
Anti-GCK antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
western blot

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human GCK,
Especie
human