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MilliporeSigma

ELANE

elastase, neutrophil expressed

Sinónimos:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
Especie:
Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), cow ELANE (100126050), dog ELANE (442980), domestic cat ELANE (100301482), Horse ELANE (100462967), domestic guinea pig Elane (100724414)
ID UniProtKB:
P08246, P09649, Q6B0D9, Q6LDP5
ID del gen:
  • Human(1991) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
  • Mouse(50701) elastase, neutrophil expressed
  • Rat(299606) elastase, neutrophil expressed
  • sheep(101110841) elastase, neutrophil expressed
  • cow(100126050) elastase, neutrophil expressed
  • dog(442980) elastase, neutrophil expressed
  • domestic cat(100301482) elastase, neutrophil expressed
  • Horse(100462967) elastase, neutrophil expressed
  • domestic guinea pig(100724414) elastase, neutrophil expressed

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
MABS461
Anticuerpo anti-elastasa de neutrófilos, clon AHN-10, clone AHN-10, from mouse,
Reactividad de especies
human
Aplicación
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
481001
Anti-Neutrophil Elastase Rabbit pAb, liquid, Calbiochem®,
Reactividad de especies
human
Aplicación
SAB5703017
Anti-Neutrophil Elastase (ELANE) Antibody, clone 8X4E6, Rabbit Monoclonal, ,
Reactividad de especies
mouse
Aplicación
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB5500151
Anti-Neutrophil Elastase antibody, Rabbit monoclonal, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunohistochemistry
ZRB1927
Anti-Neutrophil Elastase Antibody, clone 1B2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot

Proteins

Referencia del producto
Descripción
Especie
E8140
Elastase from human leukocytes, lyophilized powder, ≥50 units/mg protein (Bradford),
Especie
human
A6150
α1-Antitrypsin from human plasma, salt-free, lyophilized powder,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU003711
MISSION® esiRNA, targeting human ELANE,
Especie
human