DLAT
dihydrolipoamide S-acetyltransferase
Sinónimos:
DLTA, PDC-E2, PDCE2
Especie:
Human DLAT (1737), Mouse Dlat (235339), Rat Dlat (81654), chicken DLAT (419796), Zebrafish dlat (324201), domestic guinea pig Dlat (100735563), dog DLAT (489406), sheep DLAT (101110965), cow DLAT (512723), Horse DLAT (100062027) ...Más
ID UniProtKB:
ID del gen:
- Human(1737) Summary: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
- Mouse(235339) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
- Rat(81654) dihydrolipoamide S-acetyltransferase
- chicken(419796) dihydrolipoamide S-acetyltransferase
- Zebrafish(324201) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
- domestic guinea pig(100735563) dihydrolipoamide S-acetyltransferase
- dog(489406) dihydrolipoamide S-acetyltransferase
- sheep(101110965) dihydrolipoamide S-acetyltransferase
- cow(512723) dihydrolipoamide S-acetyltransferase
- Horse(100062027) dihydrolipoamide S-acetyltransferase
- domestic cat(101094126) dihydrolipoamide S-acetyltransferase
- Domestic Rabbit(100349212) dihydrolipoamide S-acetyltransferase
- naked mole-rat(101698667) dihydrolipoamide S-acetyltransferase
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-DLAT Antibody, clone 2Z7R10, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot
Anti-DLAT antibody produced in rabbit, IgG fraction of antiserum,
Reactividad de especies
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-DLAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DLAT antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot
Anti-DLAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot
esiRNA
Referencia del producto
Descripción
Especie