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CDK7

cyclin-dependent kinase 7

Sinónimos:
CAK1, CDKN7, HCAK, MO15, STK1, p39MO15
Especie:
ID UniProtKB:
ID del gen:
  • Human(1022) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
  • Mouse(12572) cyclin-dependent kinase 7
  • Rat(171150) cyclin-dependent kinase 7
  • domestic guinea pig(100725955) cyclin-dependent kinase 7
  • naked mole-rat(101702664) cyclin-dependent kinase 7
  • sheep(101119934) cyclin-dependent kinase 7
  • Horse(100049964) cyclin-dependent kinase 7
  • Zebrafish(405897) cyclin-dependent kinase 7
  • dog(608441) cyclin-dependent kinase 7
  • domestic cat(101086781) cyclin-dependent kinase 7
  • chicken(771294) cyclin-dependent kinase 7
  • cow(515462) cyclin-dependent kinase 7
  • fruit fly(31441) Cyclin-dependent kinase 7

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-Cdk7/CAK antibody produced in mouse, clone MO-1.1, ascites fluid,
Reactividad de especies
human
Aplicación
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

microarray

western blot
Anti-CDK7 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
Anti-phospho Cyclin-dependent kinase 7 (Thr170) Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
human, mouse, rat
Aplicación
ChIP
western blot
Anti-CDK7 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
Anti-CDK7 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Flavopiridol hydrochloride, ≥98% (HPLC), powder,
Especie
human
Roscovitine, ≥98% (TLC),
Especie
human, mouse, rat
Olomoucine, ≥98% (HPLC),
Especie
human, rat

Proteins

Referencia del producto
Descripción
Especie
Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 10 µg, Active complex of recombinant full length human Cdk7, containing a C-terminal His6-tag, recombinant full-length human Cyclin H untagged & recombinant full-length human MAT1 containing an N-terminal GST-tag, for use in Kinase Assays.,
Especie
human
CDK7/Cyclin H1/MNAT1, active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse Cdk7,
Especie
mouse
MISSION® esiRNA, targeting human CDK7,
Especie
human

Small Molecule - Substrate

Referencia del producto
Descripción
Especie
Cdk7/9tide, ,
Especie
human