BRCC3
BRCA1/BRCA2-containing complex, subunit 3
Sinónimos:
BRCC36, C6.1A, CXorf53
Especie:
Human BRCC3 (79184), Mouse Brcc3 (210766), Rat Brcc3 (316794), sheep BRCC3 (101114756), domestic cat BRCC3 (101096553), domestic guinea pig Brcc3 (100719736), dog BRCC3 (612642), cow BRCC3 (519513), chicken BRCC3 (422201), naked mole-rat Brcc3 (101719523)
ID UniProtKB:
ID del gen:
- Human(79184) Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
- Mouse(210766) BRCA1/BRCA2-containing complex, subunit 3
- Rat(316794) BRCA1/BRCA2-containing complex, subunit 3
- sheep(101114756) BRCA1/BRCA2-containing complex, subunit 3
- domestic cat(101096553) BRCA1/BRCA2-containing complex, subunit 3
- domestic guinea pig(100719736) BRCA1/BRCA2-containing complex, subunit 3
- dog(612642) BRCA1/BRCA2-containing complex, subunit 3
- cow(519513) BRCA1/BRCA2-containing complex, subunit 3
- chicken(422201) BRCA1/BRCA2-containing complex, subunit 3
- naked mole-rat(101719523) BRCA1/BRCA2-containing complex, subunit 3
- Horse(100062237) BRCA1/BRCA2-containing complex, subunit 3
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-BRCC3 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot
Anti-BRCC3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-BRCC3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
esiRNA
Referencia del producto
Descripción
Especie