Electroresponsive polymer-carbon nanotube hydrogel hybrids for pulsatile drug delivery in vivo.

Electroresponsive polymer-carbon nanotube hydrogel hybrids for pulsatile drug delivery in vivo.

Advanced healthcare materials (2012-11-28)

Ania Servant, Laura Methven, Rhodri P Williams, Kostas Kostarelos

ABSTRACT

Drug release triggered by an external non-invasive stimulus is of great interest for the development of new drug delivery systems. The preparation of an electroresponsive multiwalled carbon nanotube/poly(methylacrylic acid) (MWNT/PMAA)-based hybrid material is reported. The hydrogel hybrids achieve a controlled drug release upon the ON/OFF application of an electric field, giving rise to in vitro and in vivo pulsatile release profiles.

MATERIALS

Product Number

Brand

Product Description

434507

Sigma-Aldrich

Poly(methacrylic acid, sodium salt) solution, average M_n ~5,400, average M_w ~9,500 by GPC, 30 wt. % in H₂O

674044

Sigma-Aldrich

Poly(methacrylic acid, sodium salt) solution, average M_w 4,000-6,000, 40 wt. % in H₂O