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  • Weak bases and formation of a less soluble lauryl sulfate salt/complex in sodium lauryl sulfate (SLS) containing media.

Weak bases and formation of a less soluble lauryl sulfate salt/complex in sodium lauryl sulfate (SLS) containing media.

International journal of pharmaceutics (2011-04-30)
Shobha N Bhattachar, Donald S Risley, Pornpen Werawatganone, Aktham Aburub
ABSTRACT

This work reports on the solubility of two weakly basic model compounds in media containing sodium lauryl sulfate (SLS). Results clearly show that the presence of SLS in the media (e.g. simulated gastric fluid or dissolution media) can result in an underestimation of solubility of some weak bases. We systematically study this phenomenon and provide evidence (chromatography and pXRD) for the first time that the decrease in solubility is likely due to formation of a less soluble salt/complex between the protonated form of the weak base and lauryl sulfate anion.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ammonium lauryl sulfate solution, ~30% in H2O
Sigma-Aldrich
Lithium dodecyl sulfate, BioReagent, for molecular biology, suitable for electrophoresis
Sigma-Aldrich
Lithium dodecyl sulfate, BioXtra, ≥98.5% (GC)
Sigma-Aldrich
Lithium dodecyl sulfate, ≥98.5% (GC)