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SAB4301289

Sigma-Aldrich

Anti-phospho-BLK (pTyr501) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

B lymphocyte kinase, EC 2.7.10.2, Tyrosine-protein kinase BLK, kinase Blk, p55-BLK

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

57 kDa

species reactivity

human

concentration

1.0 mg/mL

technique(s)

immunohistochemistry: 1:50-1:100

isotype

IgG

accession no.

NP_001706.2.

UniProt accession no.

P51451

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr501)

Gene Information

human ... BLK(640)

General description

B lymphoid tyrosine kinase (BLK) protein belongs to the Src kinase family. It has an Src homology 3 (SH3) and an Src homology 2 (SH2) domain N-terminal to the catalytic kinase domain. The BLK gene is located on human chromosome 8p23.1.

Specificity

The antibody detects endogenous levels of BLK only when phosphorylated at tyrosine 501.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y(p)-E-L) derived from Human BLK.

Biochem/physiol Actions

B lymphoid tyrosine kinase (BLK) protein has oncogenic properties. It helps B-cell receptors transmit signals and may be important for B-cell repertoire development and mature B-cell activity. BLK participates in B-cell antigen receptor signaling. The BLK gene polymorphisms are linked to renal dysfunction in people with systemic lupus erythematosus.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dongsheng Di et al.
Journal of human genetics, 65(8), 675-681 (2020-04-22)
Previous studies are inconclusive on the relationships between BLK gene polymorphisms and clinical features of systemic lupus erythematosus (SLE). The present study aimed to estimate association between BLK loci and SLE clinical features in Chinese population. Associations between BLK single-nucleotide
David Leander Petersen et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(7), 1010428317714196-1010428317714196 (2017-07-04)
B-lymphoid tyrosine kinase (BLK) is a non-receptor tyrosine kinase belonging to the SRC family kinases. BLK is known to be functionally involved in B-cell receptor signaling and B-cell development. New evidence suggests that B-lymphoid tyrosine kinase is ectopically expressed and
John Ck Barber et al.
Molecular cytogenetics, 3, 3-3 (2010-02-20)
The 8p23.1 duplication syndrome and copy number variation of the 8p23.1 defensin gene cluster are cytogenetically indistinguishable but distinct at the molecular level. To our knowledge, the 8p23.1 duplication syndrome has been described at prenatal diagnosis only once and we

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