Skip to Content
MilliporeSigma
All Photos(2)

Documents

M2378

Sigma-Aldrich

Mucin from porcine stomach

Type II

Synonym(s):

MUC

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

CAS Number:
84082-64-4
EC Number:
282-010-7
MDL number:
MFCD00131629
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

Porcine stomach

type

Type II

form

powder

composition

bound sialic acid, ≤1.2%

technique(s)

cell culture | mammalian: suitable

solubility

1 M NaOH: soluble 20 mg/mL

UniProt accession no.

A0A5G2QSD1

storage temp.

2-8°C

Gene Information

pig ... MUC2(100127145)

Looking for similar products? Visit Product Comparison Guide

General description

Mucin is majorly composed of carbohydrate units, crucial for structural architecture and conformation. The monomer of mucin is 640 kDa, with protein contributing to only 20% of the molecular weight. The carbohydrate component is attached to the threonine and serine side chains. Mucins are classified into secreted and transmembrane mucins.
Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.

Application

Mucin from porcine stomach has been used:
  • in the standard curve generation for quantifying mucin-2 generated during mucosal inflammation in mice
  • as a component of digestion fluid solutions in in vitro human digestion model
  • as a component of simulated saliva fluid

Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.

Biochem/physiol Actions

Mucin has wide pharmacological applications in drug delivery. Mucins play a protective role in inflammation. Deregulation in mucin synthesis contributes to tumorigenesis and chronic inflammation.
Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mucins in cancer: function, prognosis and therapy
Kufe DW
Nature Reviews. Cancer, 9(12), 874-874 (2009)
An optimized purification process for porcine gastric mucin with preservation of its native functional properties
Schomig VJ, et al.
Royal Society of Chemistry Advances, 6(50), 44932-44943 (2016)
Structural investigation of porcine stomach mucin by X-ray fiber diffraction and homology modeling
Veluraja K, et al.
Biochemical and biophysical research communications, 406(4), 570-573 (2011)
Enhancement of the solubility, stability and bioaccessibility of quercetin using protein-based excipient emulsions
Chen X, et al.
Food Research International, 114, 30-37 (2018)
Genetic mouse models with intestinal-specific tight junction deletion resemble an ulcerative colitis phenotype
Stremmel W, et al.
Journal of Crohn's & Colitis, 11(10), 1247-1257 (2017)
View All Related Papers

Articles

Sialic Acid

Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service