G0921

6′-Guanidinonaltrindole ditrifluoroacetate dihydrate

≥97.5% (HPLC), solid

• Synonym(s): 6′-GNTI, [(4bS,8R,8aS,14bR)-7-(Cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-1,8a-dihydroxy-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazol-12-yl]-guanidine ditrifluoroacetate dihydrate
• Empirical Formula (Hill Notation): C₂₇H₂₉N₅O₃ · 2CF₃CO₂H · 2H₂O
• CAS Number: 35080-00-3
• Molecular Weight: 735.63
• MDL number: MFCD09752601
• UNSPSC Code: 12352200

Properties

• assay: ≥97.5% (HPLC)
• form: solid
• storage condition: desiccated; under inert gas
• color: pink to tan
• solubility: H₂O: >20 mg/mL
• storage temp.: −20°C
• SMILES string: O.O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.NC(=N)Nc1ccc2c3C[C@@]4(O)[C@H]5Cc6ccc(O)c7OC(c3[nH]c2c1)[C@]4(CCN5CC8CC8)c67

Description

Biochem/physiol Actions

6′-GNTI is a selective agonist of κ/δ opioid receptor heterodimers in the spinal cord and has the unique property of selectively activating only opioid receptor heterodimers and not homomers. 6′-GNT functions as an analgesic demonstrating that opioid receptor heterodimers are functionally relevant in vivo.

Caution

Air-sensitive

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)