439126

Acetone

suitable for HPLC, ≥99.9%

• Linear Formula: CH₃COCH₃
• CAS Number: 67-64-1
• Molecular Weight: 58.08
• Beilstein/REAXYS Number: 635680
• EC Number: 200-662-2
• MDL number: MFCD00008765
• UNSPSC Code: 12190000
• PubChem Substance ID: 57650186
• NACRES: NA.02

Properties

• vapor density: 2 (vs air)
• Quality Level: 100
• vapor pressure: 184 mmHg ( 20 °C)
• assay: ≥99.9%
• form: liquid
• expl. lim.: 13.2 %
• technique(s): HPLC: suitable
• impurities: ≤0.5% (water)
• evapn. residue: <0.0002%
• color: clear colorless
• refractive index: n20/D 1.359 (lit.)
• bp: 56 °C/760 mmHg (lit.)
• mp: −94 °C (lit.)
• solubility: water: miscible
• density: 0.791 g/mL at 25 °C (lit.)
• λ: H₂O reference
• UV absorption: λ: 330 nm A_max: 1.00; λ: 340 nm A_max: 0.10; λ: 350 nm A_max: 0.02; λ: 400 nm A_max: 0.01
• suitability: suitable (pesticide analysis)
• format: neat
• SMILES string: CC(C)=O
• InChI: 1S/C3H6O/c1-3(2)4/h1-2H3
• InChI key: CSCPPACGZOOCGX-UHFFFAOYSA-N

Description

General description

Acetone is a ketone. Mixtures of TiO₂ (P25) with rare earth oxides (La₂O₃ or Y₂O₃) calcined at 700°C or 650°C has been reported to efficiently photocatalyze the oxidation of acetone. Its aldol condensation in vapor-phase has been investigated over MgO promoted with alkali (Li, Na, K and Cs) or alkaline earth (Ca, Sr and Ba) metal ions. It undergoes Aldol condensation in the presence of Mg-Al layered double hydroxides (LDH) as catalysts and Cl^- and/or CO₃^2- as compensating anions to afford diacetone alcohol and mesityl oxide. Enantioselective Aldol condensation of acetone with various isatins in the presence of dipeptides (catalyst) has been described.

application

Acetone was used in the affinity purification of modified proteins using streptavidin beads for the mass spectrometric (MS) identification of poly(ADP-ribose) polymerases (PARP) substrate proteins.
It may be used in the following studies:

• NMR spectroscopic evaluation of glucose metabolism in biological samples (blood).
• Preparation of 13wt% amorphous poly (lactic acid) (PLA) solution, which was required for the preparation of electrospun PLA membranes.
• As a precursor for the synthesis of methyl isobutyl ketone (MIBK) in the presence of sulfonated graphene oxide-Pd/cordierite catalyst.
• Synthesis of (4-hydroxymethyl-2,2-dimethyl-1,3-dioxolane), a solketal from glycerol using supercritical fluids (SCF) technology.

It may be used in the synthesis of the following acetone hydrazones:

• 1-isopropylidene-2-methylhydrazine
• 1-isopropylidene-2-hydroxyethylhydrazine
• 1-isopropylidene-2-formylhydrazine

Acetone′s luminesence intensity is dependent upon the solution components . The absorption of UV light by acetone, results in its photolysis and the production of radials .

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319,H336
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Central nervous system
• supp_hazards: EUH066
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 1.4 °F - closed cup
• flash_point_c: -17.0 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves