ABE74
Anti-FoxP4 Antibody
serum, from rabbit
Synonym(s):
forkhead box P4, fork head-related protein like A, Fork head-related protein-like A, winged-helix repressor FOXP4
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Foxp4(74123)
General description
Forkhead box protein P4 (FoxP4) is a multidomain transcriptional repressor. This protein is a member of the Fox family of proteins characterized by it unique winged-helix DNA binding motif. Members of this family are known for their ability to regulate both the cell fate and differentiation of several tissues. FoxP4 acts to repress expression by inteacting with DNA. For DNA binding to occur, FoxP4 must form homodimers and heterodimers with FoxP1 and FoxP2. During embryogenesis, expression of this protein is observed in lung and brain. In adults expression is observed in adult heart, lung, brain, liver, spleen, testis and kidney. Alternative splicing result in the expression of three known isoforms.
Specificity
This antibody recognizes FoxP4.
Immunogen
Epitope: Unknown
GST-tagged recombinant protein corresponding to mouse FoxP4.
Application
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FoxP4 in HeLa cells.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Use Anti-FoxP4 Antibody (Rabbit Polyclonal Antibody) validated in ICC, WB, IHC to detect FoxP4 also known as forkhead box P4, winged-helix repressor FOXP4.
Quality
Evaluated by Western Blot in human brain cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP4 on 10 µg of human brain cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP4 on 10 µg of human brain cell lysate.
Target description
86 and 79 kDa Observed. Three known isoforms due to alternative splicing.
Physical form
Unpurified
Unpurified rabbit polyclonal serum with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
Human brain cell lysate
Human brain cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Fuhua Wang et al.
Development (Cambridge, England), 149(7) (2022-03-18)
Beige adipocytes have a discrete developmental origin and possess notable plasticity in their thermogenic capacity in response to various environmental cues, but the transcriptional machinery controlling beige adipocyte development and thermogenesis remains largely unknown. By analyzing beige adipocyte-specific knockout mice
Caroline Alayne Pearson et al.
Cell reports, 30(6), 1964-1981 (2020-02-13)
The laminar architecture of the mammalian neocortex depends on the orderly generation of distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. Here, we identify critical roles for the autism risk gene Foxp1 in maintaining aRG identity and gating
Haixia Zhao et al.
Developmental biology, 398(2), 242-254 (2014-12-21)
Osteoblast induction and differentiation in developing long bones is dynamically controlled by the opposing action of transcriptional activators and repressors. In contrast to the long list of activators that have been discovered over past decades, the network of repressors is
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