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AB9712

Sigma-Aldrich

Anti-Sortilin Antibody

serum, Chemicon®

Synonym(s):

Neurotensin receptor 3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_002959.4

UniProt accession no.

Q99523

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SORT1(6272)

General description

Neurotensin receptor 3 or sortilin (the intracellular sorting protein 95 kDa) is a member of a family of receptors characterized by a single transmembrane domain, a short intracytoplasmic domain, and a long cysteine-rich luminal extracellular domain. This receptor has been found in the brain, spinal cord, muscle and other peripheral cell types, and in cancer cells. Sortilin exhibits sequence similarities with proteins involved in intracellular transport and trafficking.

Specificity

Sortilin (Neurotensin receptor 3). By Western blot the antibody recognizes a strong band at ~90 kDa in extracts of NSC34 cells. By immunohistochemistry the antibody intensely stains motor neurons within the rat spinal cord.

Immunogen

Recombinant protein from the extracellular domain of human sortilin.

Application

Anti-Sortilin Antibody is an antibody against Sortilin for use in WB, IH.
Western blot: 1:1,000-1:2,000 on extracts from NSC34 cells.
Immunohistochemistry: 1:500-1:1,000 on rat spinal cord.

Optimal working dilutions must be determined by the end user.

Physical form

Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material.

Storage and Stability

Maintain lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (ACS grade or better) can be added 1:1 for additional stability.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kimberly S Williams et al.
Journal of neuroimmunology, 285, 76-93 (2015-07-23)
To characterize the role of neurotrophin receptors on macrophages, we investigated the ability of nerve growth factor (NGF) and its precursor, proNGF, to regulate human macrophage phenotype. The p75 neurotrophin receptor (p75(NTR)) and TrkA were concentrated within overlapping domains on

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