Skip to Content
MilliporeSigma
All Photos(1)

Documents

8.52040

Sigma-Aldrich

Fmoc-Lys(Tfa)-OH

Novabiochem®

Synonym(s):

Fmoc-Lys(Tfa)-OH, N-α-Fmoc-N-ε-trifluoroacetyl-L-lysine

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C23H23F3N2O5
CAS Number:
Molecular Weight:
464.43
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

product line

Novabiochem®

assay

≥97% (TLC)
≥97.0% (HPLC)
≥97.0% (acidimetric)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

150-160 °C

application(s)

peptide synthesis

functional group

amine

storage temp.

2-30°C

InChI

1S/C23H23F3N2O5/c24-23(25,26)21(31)27-12-6-5-11-19(20(29)30)28-22(32)33-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18/h1-4,7-10,18-19H,5-6,11-13H2,(H,27,31)(H,28,32)(H,29,30)/t19-/m0/s1

InChI key

ZVLMWTPNDXNXSZ-IBGZPJMESA-N

General description

Building block for introduction of lysine amino-acid residues bearing orthogonal side-chain protection. The trifluoroacetyl group can be selectively removed by aqueous basic hydrolysis [1,2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] E. Atherton, et al. (1980) J. Chem. Soc., Chem. Commun., 970.
[2] D. A. Stetsenko & M. J. Gait (2001) Bioconjugate Chem., 12, 576.

Linkage

Replaces: 04-12-1083

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Purity (TLC(0811)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service