648485-M

TrpA1 Antagonist, HC-030031

The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(s): TrpA1 Antagonist, HC-030031, HC-030031
• Empirical Formula (Hill Notation): C₁₈H₂₁N₅O₃
• CAS Number: 349085-38-7
• Molecular Weight: 355.39
• MDL number: MFCD02007349
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 50 mg/mL, clear, colorless
• storage temp.: 2-8°C
• SMILES string: [n]2(c3c(nc2)N(C(=O)N(C3=O)C)C)CC(=O)Nc1ccc(cc1)C(C)C
• InChI: 1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
• InChI key: HEQDZPHDVAOBLN-UHFFFAOYSA-N

Description

General description

A cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.

Warning

Toxicity: Standard Handling (A)

Other Notes

Taylor-Clark, T., et al. 2008. Mol. Pharmacol.73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A.104, 13525.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable