239783

Cyclooxygenase Inhibitor Set

The Cyclooxygenase Inhibitor Set controls the biological activity of Cyclooxygenase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Contains 100 mg of Meloxicam (Cat. No. 444800), 5 mg of NS-398 (Cat. No. 349254), 5 mg of SC-560 (Cat. No. 565610), and 5 mg of Sulindac Sulfide (Cat. No. 574102).

Cyclooxygenases (COX) act on arachidonic acid to generate prostaglandins. They exist either as COX-1 or COX-2. COX-1, a constitutive enzyme associated with the endoplasmic reticulum, is responsible for maintaining normal physiologic function. It is found throughout the body, especially in the GI tract, kidneys, and platelets and its inhibition by NSAID is reported to cause GI damage, renal dysfunction, and platelet abnormalities. COX-2 is an inducible enzyme that is mainly associated with the nuclear envelope. It′s activity is induced by several growth factors, cytokines, and inflammatory signals. COX-2 expression is markedly increased in 85-90% of human colorectal adenocarcinomas, whereas COX-1 levels remain unchanged. Based on structural differences in the active sites of these isozymes, a new drug has been developed that specifically inhibits only the COX-2 activity. COX-2 inhibitors have the potential to provide the traditional benefits of NSAID with significantly reduced incidence of endoscopic ulcers. Hence, they offer greater therapeutic promise in the treatment of inflammation and cancer. This inhibitor set provides 4 inhibitors for testing the inhibitory effects on COX-1 and COX-2.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
COX-1

Secondary Target
COX-2

Packaging

Packaged under inert gas

Warning

Toxicity: Multiple Toxicity Values, refer to MSDS (O)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Fournier, D.B., et al. 2000. J. Cell Biochem.77, 97.
Crofford, L.J., et al. 2000. Arthritis Rheum.43, 4.
Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci.889, 84.
Williams, C., et al. 1999. Ann. N. Y. Acad. Sci.889, 72.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H317,H334,H361
• pcodes: P202 - P261 - P264 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects