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904643

Sigma-Aldrich

Thiol functionalized gelatin

Synonym(s):

Functionalized gelatin, Gelatin thiol, Gelatin-SH• Gel-SH, SH functionalized gelatin, Thiol functionalized gelatin, Thiol gelatin, Thiolated gelatin

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About This Item

UNSPSC Code:
12352105
NACRES:
NA.23

description

NMR: Conforms to structure
Thiol content 150-350 μmol/g

assay

150-350 μmol/g (Free Thiol Concentration by UVVI, UV-vis)

form

powder

color

white to pale yellow

storage temp.

−20°C

Application

Gelatin has received significant attention in the biomedical field due to its inherent bioactivity. Functionalized gelatin can be cross-linked with the formation of covalent bonds into highly crosslinked structures, such as hydrogels. Recent literature suggests that radical-mediated polymerized hydrogels may not be ideal for cell and protein encapsulation due to radical-mediated damage, hindered molecular transport, or altered cell-cell/cell-material interactions. Thiol-modified gelatin can be used to form hydrogels with multifunctional norbornene or allyl crosslinkers via thiol-ene click or Michael-addition reactions.
To improve solubility in water, heat to 40°C and stir for 10-15 minutes.

Caution

Material should be handled under nitrogen - air/oxygen & moisture are to be avoided.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Modular Cross-Linking of Gelatin-Based Thiol?Norbornene Hydrogels for in Vitro 3D Culture of Hepatocellular Carcinoma Cells
Greene T, et al
ACS biomaterials science & engineering, 1 (12), 1314?1323-1314?1323 (2015)
Gelatin hydrogels formed by orthogonal thiol?norbornene photochemistry for cell encapsulation
Munoz Z, et al.
Biomaterials Science, 2, 1063-1072 (2014)
Vinh X Truong et al.
Biomacromolecules, 18(3), 757-766 (2017-02-15)
Swelling of hydrogels leads to a decrease in mechanical performance coupled with complications in solute diffusion. In addition, hydrogel swelling affects patient safety in biomedical applications such as compression of tissue and fluid blockage. A conventional strategy for suppressing swelling

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