SRP6590
Core Histones human
≥95% (SDS-PAGE)
Synonym(s):
HeLa Core Histones
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
assay
≥95% (SDS-PAGE)
form
liquid
packaging
pkg of 50 and 100 μg
concentration
1 mg/mL
technique(s)
cell based assay: suitable
shipped in
dry ice
storage temp.
−70°C
General description
A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Further, histone H1 combines with these histones to form 30nm fibers. These fibers have six nucleosomes per turn in a solenoid arrangement. Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.
Physical form
50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.
Zhang Y and Reinberg D
Genes & Development, 15(18), 2343-2360 (2001)
Roberto Fabian et al.
Molecules (Basel, Switzerland), 26(16) (2021-08-28)
We report data from single molecule studies on the interaction between single DNA molecules and core histones using custom-designed horizontal magnetic tweezers. The DNA-core histone complexes were formed using λ-DNA tethers, core histones, and NAP1 and were exposed to forces
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