SRP4688
Prolactin from mouse
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
Luterotropic hormone, Lutetropin, Mammotropin, PRL
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
mouse
recombinant
expressed in E. coli
assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~22.5 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Prl(256249)
General description
Prolactin (PRL, also known as mammotrophin, luterotropic hormone, and lutetropin) is a neuroendocrine hormone secreted by the pituitary gland. It belongs to the cytokine receptor superfamily. Recombinant mouse prolactin is a 22.5kDa globular protein containing 198 amino acid residues.
Application
PRL (Prolactin) from mouse has been used to study the effects of prolactin on the length, motility and viability of larvae of Toxocara canis.
Prolactin from mouse has been used as a supplement in mammary epithelial basal medium (MEBM) for mammary epithelial cell culture.
Biochem/physiol Actions
PRL (Prolactin) primary function is to promote and maintain lactation during pregnancy and suckling. In addition, prolactin plays an immune-regulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. In mice, prolactin also prevents hepatocellular carcinoma by suppressing MAP3K (mitogen-activated protein kinase kinase kinase)-dependent activation of c-myc.
Prolactin synthesis is regulated in the hypothalamus. Dopamine and prolactin secretion from anterior pituitary lactotrophs are controlled by a negative feedback loop. Prolactin modulates xenobiotic metabolism by controlling the mRNA expression cytochrome p450 enzymes.
Physical form
Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 8.0 plus 50 mM NaCl.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice.
Hartwell HJ
Proceedings of the National Academy of Sciences of the USA, 111, 11455-11455 (2014)
Prolactin transport into mouse brain is independent of prolactin receptor.
Brown RS
Faseb Journal, 30, 1002-1010 (2016)
Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like disease.
Legorreta-Haquet MV
Clinical & Developmental Immunology, doi: 10- doi: 10 (2013)
L E Chávez-Güitrón et al.
Experimental parasitology, 198, 1-6 (2019-01-12)
The in vitro effect of progesterone in T. canis larvae on their enlargement and motility were evaluated, together to the possible presence of progesterone receptors (PRs). T. canis larvae were cultured in RPMI-1640 with different concentrations of progesterone (0, 20
Hui Li et al.
American journal of physiology. Gastrointestinal and liver physiology, 320(2), G183-G192 (2020-11-19)
Gastric vagal afferents (GVAs) sense food-related mechanical stimuli and signal to the central nervous system, to integrate control of meal termination. Pregnancy is characterized by increased maternal food intake, which is essential for normal fetal growth and to maximize progeny
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