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S3066

Sigma-Aldrich

SKF-89626 hydrobromide

>98% (HPLC), solid

Synonym(s):

4-(3,4-Dihydroxyphenyl)-4,5,6,7-tetrahydro­thieno[2,3-c]pyridine

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About This Item

Empirical Formula (Hill Notation):
C13H13NO2S · HBr
Molecular Weight:
328.22
MDL number:
MFCD04040024
UNSPSC Code:
12352200
PubChem Substance ID:
24278702

assay

>98% (HPLC)

form

solid

color

white

solubility

H2O: soluble 11 mg/mL

SMILES string

Br[H].Oc1ccc(cc1O)C2CNCc3sccc23

InChI

1S/C13H13NO2S.BrH/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13;/h1-5,10,14-16H,6-7H2;1H

InChI key

QAIGGSDECIJPNW-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Application

SKF-89626 hydrobromide may be used in dopaminergic cell signaling studies.

Biochem/physiol Actions

SKF-89626 is an isoquinoline derivative that fully antagonizes dopamine D1 receptor and stimulates adenylate cyclase and modulates dopaminergic-mediated cell responses.
D1 dopamine receptor agonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E B Nielsen et al.
European journal of pharmacology, 160(2), 253-262 (1989-01-31)
Dopamine (DA) D-1 and D-2 receptor agonists and antagonists were characterized in receptor binding and adenylate cyclase assays with respect to affinity, selectivity and efficacy. The ability of the ligands to interact with the discriminative stimulus effects of d-amphetamine (AMPH)
P H Andersen et al.
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds

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