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D0758

Sigma-Aldrich

2′-Deoxyinosine 5′-triphosphate trisodium salt

synthetic, 95-97%

Synonym(s):

dITP-Na3

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About This Item

Empirical Formula (Hill Notation):
C10H12N4Na3O13P3
CAS Number:
95648-77-4
Molecular Weight:
558.11
EC Number:
306-018-8
MDL number:
MFCD00167408
UNSPSC Code:
41106305
PubChem Substance ID:
24893291

biological source

synthetic

assay

95-97%

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1C[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H15N4O13P3.3Na/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;;/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19);;;/q;3*+1/p-3/t5-,6+,7+;;;/m0.../s1

InChI key

FHYSVBOUQFJKCI-PWDLANNDSA-K

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Application

2′-Deoxyinosine 5-triphosphate (dITP) may be formed by nitrosative deamination processes such as those that deaminate adenosine in DNA and RNA. dITP may be useful in studies of this process.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T Auer et al.
Nucleic acids research, 24(24), 5021-5025 (1996-12-15)
The ability to selectively amplify RNA in the presence of genomic DNA of analogous sequence is cumbersome and requires implementation of critical controls for genes lacking introns. The convenient approaches of either designing oligonucleotide primers at the splice junction or
Gel compressions and artifact banding can be resolved in the same DNA sequence reaction.
K W McCrea et al.
BioTechniques, 15(5), 843-844 (1993-11-01)
ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.
Sakumi K, Abolhassani N, et al.
Mutation Research, 703, 4-50 (2010)
Yoshihito Ueno et al.
Bioorganic & medicinal chemistry, 12(24), 6581-6586 (2004-11-24)
In this paper, we describe the synthesis and thermal stabilities of the triplexes containing either 2'-deoxyinosine (1) or 2'-deoxyxanthosine (3) in their second strands. It was found that the triplexes with the 2'-deoxy-5-methylcytidine(dM)*1:dC and dM*1:dA base triplets are thermally stable
Daisuke Tsuchimoto et al.
Mutation research, 703(1), 37-42 (2010-06-15)
To identify novel nucleotide pool sanitizing enzymes, we have established a comprehensive screening system for damaged nucleotide-binding proteins based on proteomics technology. In the screening system, affinity chromatography with resins carrying various damaged nucleotides is used for the purification of
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