76200

D-Panthenol

≥98.0% (NT)

• Synonym(s): (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B
• Empirical Formula (Hill Notation): C₉H₁₉NO₄
• CAS Number: 81-13-0
• Molecular Weight: 205.25
• Beilstein/REAXYS Number: 1724947
• EC Number: 201-327-3
• MDL number: MFCD00065006
• UNSPSC Code: 12352104
• PubChem Substance ID: 57652627
• NACRES: NA.28

Properties

• biological source: synthetic
• assay: ≥98.0% (NT)
• form: liquid
• optical activity: [α]20/D +30±1°, c = 5% in H₂O
• impurities: ≤0.002% heavy metals; ≤0.5% 3-aminopropanol
• ign. residue: ≤0.1% (as SO₄)
• color: colorless
• refractive index: n20/D 1.496-1.500
• density: 1.20 g/mL at 20 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CC(C)(CO)[C@@H](O)C(=O)NCCCO
• InChI: 1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1
• InChI key: SNPLKNRPJHDVJA-ZETCQYMHSA-N

Description

Application

• The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE(2) synthesis by keratinocytes.: This study investigates the protective effects of D-panthenol, combined with other compounds, against UVB-induced inflammation in keratinocytes. The results highlight D-panthenol′s role in skin care formulations aimed at reducing UV-induced damage and inflammation (Tan et al., 2024).


• Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury.: This research explores the protective properties of D-panthenol in mitigating acute kidney injury caused by rhabdomyolysis. The findings suggest potential therapeutic applications for D-panthenol in renal protection and recovery (Semenovich et al., 2022).


• Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery.: This clinical study examines the efficacy of eye drops containing D-panthenol in patients undergoing cataract surgery, demonstrating its potential to enhance postoperative recovery and eye health (Martone et al., 2022).


• Common Cosmetic Compounds Can Reduce Air Pollution-Induced Oxidative Stress and Pro-Inflammatory Response in the Skin.: This study highlights the role of D-panthenol in protecting the skin against oxidative stress and inflammation caused by air pollution, emphasizing its importance in cosmetic formulations for urban environments (Hergesell et al., 2022).

Biochem/physiol Actions

D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves