D27802

1,4-Diazabicyclo[2.2.2]octane

ReagentPlus^®, ≥99%

• Synonym(s): TED, Triethylenediamine
• Empirical Formula (Hill Notation): C₆H₁₂N₂
• CAS Number: 280-57-9
• Molecular Weight: 112.17
• Beilstein/REAXYS Number: 103618
• EC Number: 205-999-9
• MDL number: MFCD00006689
• UNSPSC Code: 12352100
• PubChem Substance ID: 57654087
• NACRES: NA.21

Properties

• vapor pressure: 2.9 mmHg ( 50 °C)
• Quality Level: 200
• product line: ReagentPlus^®
• assay: ≥99%
• form: crystals
• greener alternative product characteristics: Catalysis; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• refractive index: n20/D 1.4634 (lit.)
• mp: 156-159 °C (lit.)
• density: 1.02 g/mL at 25 °C (lit.)
• greener alternative category: , Aligned
• SMILES string: N12CCN(CC2)CC1
• InChI: 1S/C6H12N2/c1-2-8-5-3-7(1)4-6-8/h1-6H2
• InChI key: IMNIMPAHZVJRPE-UHFFFAOYSA-N

Description

General description

1,4-Diazabicyclo[2.2.2]octane (DABCO) is a bicyclic compound used as a strong base and catalyst in organic synthesis.

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1,4-Diazabicyclo[2.2.2]octane (DABCO, triethylenediamine), a caged tertiary diamine, is a commonly used strong hindered amine base in chemical synthesis. It can also be employed as a complexing ligand and as a catalyst. Its gas-phase electronic absorption spectrum, vibrational spectra, multiphoton ionization (MPI), and two-photon fluorescence excitation (TPFE) spectra have been recorded and analyzed. Proton magnetic resonance (PMR) studies of DABCO in solid state were conducted in order to determine its line width, second moment, and spin-lattice relaxation time.

Application

1,4-Diazabicyclo[2.2.2]octane (DABCO) may be used in the synthesis of isoxazole derivatives via dehydration of primary nitro compounds in the presence of dipolarophiles. DABCO may be used in the preparation of the following:

• DABCO bis(perhydrate)
• DABCO monohydrate
• DABCO hexahydrate

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H228,H302,H315,H318
• pcodes: P210 - P240 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Sol. 1 - Skin Irrit. 2
• Storage Class: 4.1B - Flammable solid hazardous materials
• wgk_germany: WGK 1
• flash_point_f: 144.0 °F - closed cup
• flash_point_c: 62.2 °C - closed cup
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges