710333P
Avanti
16:0 Cardiolipin
Avanti Research™ - A Croda Brand
Synonym(s):
1′,3′-bis[1,2-dipalmitoyl-sn-glycero-3-phospho]-glycerol (sodium salt)
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About This Item
Empirical Formula (Hill Notation):
C73H140Na2O17P2
CAS Number:
Molecular Weight:
1397.81
UNSPSC Code:
51191904
NACRES:
NA.25
Recommended Products
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (710333P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane, which makes up to 20% of total lipids. It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup.
Cardiolipins are anionic teraacylphospholipid, present in inner mitochondrial membrane eukaryotic cells and bacterial cytoplasmic membranes. 16:0 cardiolipin is synthesized by de novo pathway. 16:0 Cardiolipin binds to myeloid differentiation protein 2 (MD2).
The 16:0 number indicates the fatty acyl substituents attached to the carbons of glycerol.
application
16:0 Cardiolipin might be suitable to assay mitochondrial fractions for CL-specific phospholipase activity.
Biochem/physiol Actions
Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.
Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy. The association of cardiolipin and cytochrome c determines the action of proteins involved in oxidative phosphorylation and apoptosis.
Cardiolipin regulates the dynamic organization of membranes and cell division. It is involved in proton uptake pathway. Cardiolipin plays an important role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It modulates cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.
Packaging
5 mL Amber Glass Screw Cap Vial (710333P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
also commonly purchased with this product
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
755.6 - 820.4 °F
flash_point_c
402 - 438 °C
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast
Beranek A, et al.
The Journal of biological chemistry, 284(17), 11572-11578 (2009)
Cardiolipin, alpha-d-glucopyranosyl, and l-lysylcardiolipin from Gram-positive bacteria: FAB MS, monofilm and X-ray powder diffraction studies
Gutberlet T, et al.
Biochimica et Biophysica Acta - Biomembranes, 1463(2) null
The role of cardiolipin in cardiovascular health
Shen Z, et al.
BioMed Research International, 2015 (2015)
Irina M Le-Deygen et al.
Chemistry and physics of lipids, 228, 104891-104891 (2020-02-15)
Most drugs besides their intended activity, express undesired side effects, including those with the engagement of cell membrane. Previously, such undesired nonspecific effects on the membrane have been shown for a number of widely used nonsteroidal anti-inflammatory drugs. In this
Myocardial Regulation of Lipidomic Flux by Cardiolipin Synthase SETTING THE BEAT FOR BIOENERGETIC EFFICIENCY
Kiebish MA, et al.
The Journal of Biological Chemistry, 287(30), 25086-25097 (2012)
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