250376

4-Formylmorpholine

99%

• Synonym(s): 4-Morpholinecarboxaldehyde
• Empirical Formula (Hill Notation): C₅H₉NO₂
• CAS Number: 4394-85-8
• Molecular Weight: 115.13
• Beilstein/REAXYS Number: 110293
• EC Number: 224-518-3
• MDL number: MFCD00006170
• UNSPSC Code: 12352100
• PubChem Substance ID: 24855051
• NACRES: NA.22

Properties

• assay: 99%
• form: solid
• refractive index: n20/D 1.485 (lit.)
• bp: 236-237 °C (lit.)
• mp: 20-23 °C (lit.)
• density: 1.145 g/mL at 25 °C (lit.)
• SMILES string: [H]C(=O)N1CCOCC1
• InChI: 1S/C5H9NO2/c7-5-6-1-3-8-4-2-6/h5H,1-4H2
• InChI key: LCEDQNDDFOCWGG-UHFFFAOYSA-N

Description

General description

Treatment of 4-formylmorpholine with sulphur tetrafluoride in the presence of potassium fluoride gives 4-(trifluoromethyl)morpholine in excellent yields. 4-Formylmorpholine reacts with series of 2-alkyl-2-cyclohexen-1-ones in the presence of POCl₃ to give the corresponding 3-alkyl-2-chloro-5,6-dihydrobenzaldehydes and allylic alcohols (by-product).

Application

4-Formylmorpholine has been used in the preparation of:

• adenine hydrochloride labelled with ¹⁴C
• terphenyl dialdehyde

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 244.4 °F - DIN 51758
• flash_point_c: 118 °C - DIN 51758
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)