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141666

Sigma-Aldrich

1-(2-Aminoethyl)piperidine

98%

Synonym(s):

2-Piperidinoethylamine

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About This Item

Empirical Formula (Hill Notation):
C7H16N2
CAS Number:
27578-60-5
Molecular Weight:
128.22
Beilstein/REAXYS Number:
103469
EC Number:
248-540-8
MDL number:
MFCD00006516
UNSPSC Code:
12352100
PubChem Substance ID:
24848506

assay

98%

form

liquid

refractive index

n20/D 1.473 (lit.)

bp

186 °C (lit.)

density

0.899 g/mL at 25 °C (lit.)

SMILES string

NCCN1CCCCC1

InChI

1S/C7H16N2/c8-4-7-9-5-2-1-3-6-9/h1-8H2

InChI key

CJNRGSHEMCMUOE-UHFFFAOYSA-N

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General description

1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

Application

1-(2-Aminoethyl)piperidine was used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead. It was used in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel.
Reactant for synthesis of:
Analogs of anticancer agents
Inhibitor of Botulinum Neurotoxin Serotype A light Chain, P. falciparum Malaria, and Ebola Filovirus
Cannabinoid CB1 receptor antagonists
Small molecules that restore E-cadherin expression and reduve invasion in colorectal carcinoma cells
Potent and selective 5-HT6 antagonists
N-mustards as anticancer agents

pictograms

FlameCorrosion
GHS02,GHS05

signalword

Danger

hcodes

H226,H314

Hazard Classifications

Flam. Liq. 3 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

136.4 °F - closed cup

flash_point_c

58 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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First structural characterisation of nitro-nitrito linkage isomers of nickel (II): synthesis and single crystal structures of [NiL2 (NO2) 2] and [NiL2 (ONO) 2][La= a1-(2-aminoethyl) piperidine].
Das D, et al.
J. Chem. Soc., Dalton Trans., 23, 3987-3990 (1998)
Dorota Jermakowicz-Bartkowiak
Environmental geochemistry and health, 32(4), 317-320 (2010-04-14)
Vinylbenzyl chloride/divinylbenzene gel copolymer beads have been modified using piperidine, hexamethyleneimine, piperazine, 1-(2-aminoethyl)piperazine, and N-cyclohexyl-1,3-propanediamine. These resins were then tested for the sorption of noble metal ions, namely, Re(VII), Pd(II), Pt(IV), and Au(III), from a 0.1 M HCl solution. The
Sujit Sasmal et al.
Inorganic chemistry, 50(12), 5687-5695 (2011-05-31)
The work in this paper presents the syntheses, structures, and magnetic properties of three end-to-end (EE) azide/cyanate-bridged copper(II) compounds [Cu(II)L(1)(μ(1,3)-NCO)](n)·2nH(2)O (1), [Cu(II)L(1)(μ(1,3)-N(3))](n)·2nH(2)O (2), and [Cu(II)L(2)(μ(1,3)-N(3))](n) (3), where the ligands used to achieve these species, HL(1) and HL(2), are the tridentate

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