- New air-stable catalysts for general and efficient suzuki-miyaura cross-coupling reactions of heteroaryl chlorides.
New air-stable catalysts for general and efficient suzuki-miyaura cross-coupling reactions of heteroaryl chlorides.
Organic letters (2006-04-21)
Anil S Guram, Anthony O King, John G Allen, Xianghong Wang, Laurie B Schenkel, Johann Chan, Emilio E Bunel, Margaret M Faul, Robert D Larsen, Michael J Martinelli, Paul J Reider
PMID16623551
ABSTRACT
[reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10,000 TON) are observed.