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Key Documents

8.04918

Sigma-Aldrich

Potassium tert-butylate

for synthesis

Synonym(s):

Potassium tert-butylate

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About This Item

Linear Formula:
(CH3)3COK
CAS Number:
865-47-4
Molecular Weight:
112.21
MDL number:
MFCD00012162
UNSPSC Code:
12352107
EC Index Number:
212-740-3
NACRES:
NA.22

vapor pressure

0.02 hPa ( 20 °C)

Quality Level

200

Assay

≥98.0% (acidimetric)

form

powder

autoignition temp.

483 °C

pH

13 (20 °C, 5 g/L in H2O, Hydrolysis)

mp

256-258 °C

density

1.19 g/cm3 at 20 °C

bulk density

500 kg/m3

storage temp.

2-30°C

InChI

1S/C4H9O.K/c1-4(2,3)5;/h1-3H3;/q-1;+1

InChI key

LPNYRYFBWFDTMA-UHFFFAOYSA-N

General description

Potassium tert-butylate (Potassium tert-Butoxide) is a strong, non-nucleophilic alkoxide base in organic chemistry. Potassium tert-butoxide catalyzes the reaction of hydro silanes and heterocyclic compounds to generate the silyl derivatives. It is used to catalyze the Michael addition reaction, Ramberg-Baecklund reaction, Pinacol rearrangement.

Application

Potassium tert-butylate is used to catalyzes the Michael addition reaction.

Analysis Note

Assay (acidimetric): ≥ 98,0 %(m)
Free KOH: ≤ 1 %(m)
Identity (IR): conforms

Pictograms

FlameCorrosion
GHS02,GHS05

Signal Word

Danger

Hazard Statements

H228 - H252 - H260 - H314

Hazard Classifications

Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 2 - Skin Corr. 1A - Water-react 1

Supplementary Hazards

EUH014

Storage Class Code

4.2 - Pyrophoric and self-heating hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Synthesis of N-substituted quaternary carbon centers through KO t-Bu-catalyzed aza-Michael addition of pyrazoles to cyclic enones
Yoon S, et al.
Organic & Biomolecular Chemistry, 20(42), 8313-8322 (2022)
Anton A Toutov et al.
Nature, 518(7537), 80-84 (2015-02-06)
Heteroaromatic compounds containing carbon-silicon (C-Si) bonds are of great interest in the fields of organic electronics and photonics, drug discovery, nuclear medicine and complex molecule synthesis, because these compounds have very useful physicochemical properties. Many of the methods now used

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