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345733-M

Millipore

Ganglioside GM3, Monosialo, Ammonium Salt, Bovine Milk

Contains mainly N-acetylneuraminic acid.

Synonym(s):

Ganglioside GM3, Monosialo, Ammonium Salt, Bovine Milk, Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄

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About This Item

Empirical Formula (Hill Notation):
C64H118N2O21 · NH4
Molecular Weight:
1269.66
UNSPSC Code:
12352211

Quality Level

Assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

chloroform/methanol (2:1): soluble

storage temp.

−20°C

General description

Contains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
Contains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC50 = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
M.W. 1198.5 (based on stearoyl - 18:0).

Biochem/physiol Actions

Primary Target
Protein kinase C, EGF-receptor tyrosine kinase
Target IC50: 100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions

Warning

Toxicity: Irritant (B)

Other Notes

Katoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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