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850356P

Avanti

4ME 16:0 PC

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-Diphytanoyl-3-sn-phosphatidylcholine, 1,2-di-(3,7,11,15-tetramethylhexadecanoyl)-sn-glycero-3-phosphocholine; PC(16:0(3me,7me,11me,15me)/16:0(3me,7me,11me,15me)), DPhPC, Diphytanoylphosphatidylcholine

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About This Item

Empirical Formula (Hill Notation):
C48H96NO8P
CAS Number:
207131-40-6
Molecular Weight:
846.25
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-diphytanoyl-sn-glycero-3-phosphocholine

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 200 mg ((850356P-200MG))
pkg of 1 × 25 mg ((850356P-25MG))
pkg of 1 × 500 mg ((850356P-500MG))

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)=O

General description

Lipids containing diphytanoyl fatty acid chains have been used to produce stable planar lipid membranes (see References). Diphytanoyl phosphatidylcholine does not exhibit a detectable gel to liquid crystalline phase transition from -120°C to +120°C.The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis.

Application

4ME 16:0 PC has been used:
  • in the electrophysiology studies of chloride channel
  • for the generation of Droplet-Hydrogel Bilayer (DHB), which is used for protein reconstitution studies
  • for the generation of lipid bilayers for single channel and ion selectivity measurements studies

Biochem/physiol Actions

1,2-diphytanoyl-sn-glycero-3-phosphocholine (4ME 16:0 PC) or DPhPC has choline head groups and favors formation of membrane lipid bilayer. It displays low permeability towards ions and water. DPhPC is majorly used lipid for electrophysiological measurements and ion conductivity studies.

Packaging

20 mL Clear Glass Screw Cap Vial (850356P-200mg)
30 mL Amber Wide Mouth Bottle with Screw Cap (850356P-500mg)
5 mL Clear Glass Sealed Ampule (850356P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Patrick Urban et al.
Langmuir : the ACS journal of surfaces and colloids, 34(44), 13368-13374 (2018-10-23)
Controlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying and emulating membrane functionality in synthetic biological systems. Here, we demonstrate an approach to reversibly control lipid
H Lindsey et al.
Biochimica et biophysica acta, 555(1), 147-167 (1979-07-19)
We report here on a series of studies aimed at characterization of the structural and dynamical properties of the synthetic lipid diphytanoyl phosphatidylcholine, in multilamellar dispersions and vesicle suspensions. The lipid exhibits no detectable gel to liquid crystalline phase transition
Zahra Aminipour et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 146, 133-142 (2019-11-08)
Doxorubicin is an anti-cancer drug that is important for breast cancer therapy. In this study, the effects of the membrane potential of breast cancer cells (-30 mV) and normal breast epithelial cells (-60 mV) on doxorubicin (DOX) permeability was studied. To achieve
Tim Diederichs et al.
Nature communications, 10(1), 5018-5018 (2019-11-07)
Nanopores are key in portable sequencing and research given their ability to transport elongated DNA or small bioactive molecules through narrow transmembrane channels. Transport of folded proteins could lead to similar scientific and technological benefits. Yet this has not been
Physical properties of bilayer membranes formed from a synthetic saturated phospholipid in n-decane.
W R Redwood et al.
Biochimica et biophysica acta, 233(1), 1-6 (1971-03-09)
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