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860417

Sigma-Aldrich

Salicylamide

99%

Synonym(s):

2-Hydroxybenzamide

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About This Item

Linear Formula:
2-(HO)C6H4CONH2
CAS Number:
65-45-2
Molecular Weight:
137.14
Beilstein:
742439
EC Number:
200-609-3
MDL number:
MFCD00007978
UNSPSC Code:
12352100
PubChem Substance ID:
24888510
NACRES:
NA.22

Assay

99%

form

solid

mp

140-144 °C (lit.)

SMILES string

NC(=O)c1ccccc1O

InChI

1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)

InChI key

SKZKKFZAGNVIMN-UHFFFAOYSA-N

Gene Information

human ... AR(367)

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General description

Salicylamide is used as a starting material for synthesizing substituted salicylamides through acylation reactions.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Acylation of salicylamide to 5-acetylsalicylamide using ionic liquids as dual catalyst and solvent
Chen, W et al.
Journal of Industrial and Engineering Chemistry, 16(5), 800-804 (2010)
Patricia D Sauzem et al.
European journal of medicinal chemistry, 43(6), 1237-1247 (2007-09-25)
In this work, we reported the synthesis and evaluation of the analgesic and anti-inflammatory properties of novel 3- or 4-substituted 5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-1-carboxyamidepyrazoles (where 3-/4-substituent=H/H, Me/H, Et/H, Pr/H, i-Pr/H, Bu/H, t-Bu/H, Ph/H, 4-Br-Ph/H and H/Me) designed in the exploration of the bioisosteric
R Dolezal et al.
European journal of medicinal chemistry, 44(2), 869-876 (2008-06-13)
Quantitative relationships between the molecular structure and the biological activity of 49 isosteric salicylamide derivatives as potential antituberculotics with a new mechanism of action against three Mycobacterial strains were investigated. The molecular structures were represented by quantum chemical B3LYP/6-31G( *)
J A Murillo Pulgarín et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 909-914 (2011-05-13)
A new methodology for the simultaneous determination of salicylic acid and salicylamide in biological fluids is proposed. The strong overlapping of the fluorescence spectra of both analytes makes impossible the conventional fluorimetric determination. For that reason, the use of fluorescence
Carlos Barea et al.
Bioorganic & medicinal chemistry letters, 21(15), 4498-4502 (2011-07-05)
Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain
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