- c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators.
c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators.
Chemical communications (Cambridge, England) (2011-03-15)
Shizuka Nakayama, Ilana Kelsey, Jingxin Wang, Herman O Sintim
PMID21399808
ABSTRACT
The ubiquitous bacterial biofilm regulator, c-di-GMP can form G-quadruplexes at physiological conditions in the presence of some aromatic compounds, such as acriflavine and proflavine. The fluorescence of these compounds is quenched upon c-di-GMP binding and some of the formed c-di-GMP G-quadruplexes are stable even at 75 °C.