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Key Documents

SAB2900692

Sigma-Aldrich

Anti-NTSR1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

NT-1r, NT1 receptor, NTR, NTS1, NTSR1, Neurotensin receptor type 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: 6 μg/mL

UniProt accession no.

P30989

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NTSR1(4923)

General description

The neurotensin receptor 1 (NTSR1) gene has 4 exons and 3 introns and is 53.93 Kb long. NTSR1 is a member of the G protein-coupled receptor (GPCR) family. It consists of 4 extracellular and intracellular loops. It is expressed in the amygdal nucleus, ventral tegmental area, substantia nigra, striatum and entorhinal, and prefrontal cortices of the central nervous system.

Immunogen

Synthetic 18 amino acid peptide from N-terminal extracellular domain of human NTSR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Elephant (94%); Marmoset (89%); Hamster (83%).

Application

Anti-NTSR1 antibody produced in rabbit has been used in immunohistochemistry (IHC) (1:500).

Biochem/physiol Actions

The neurotensin receptor 1 (NTSR1) plays a regulatory role in the initiation, proliferation, apoptosis, metastasis, and differentiation of tumors through several pathways. Overexpression of NTSR1 is seen in lung cancer, malignant prostatic tumors, and malignant cell lines. NTSR1 is a risk factor that participates in the progression of ductal breast cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Supplied at 1 mg/ml

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ankit Mishra et al.
Drug and chemical toxicology, 1-12 (2021-08-03)
The interaction between neuroendocrine and immune components of the gut maintains the organism's physical and psychological health. Its disruption may reflect in disease conditions such as inflammatory bowel disease (IBD) and mental illness. The lipopolysaccharide (LPS) disrupts the endocrine-immune homeostasis
NTSR1 (neurotensin receptor 1 (high affinity))
Saada S, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2014)
Huan-rong Hu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 40(13), 2524-2536 (2015-12-25)
As a neuropeptide, neurotensin (NTS) is widely expressed in central and peripheral nervous system, which is mainly mediated byneurotensin receptor1 (NTSR1) to activate the related downstream signaling pathways. After summarized the function and mechanism of NTS/NTSR1 in various malignant tumors

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