S006

Ketanserin (+)-tartrate salt

≥97%, solid

• Synonym(s): 3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt, R 41468 (+)-tartrate salt
• Empirical Formula (Hill Notation): C₂₂H₂₂FN₃O₃ · C₄H₆O₆
• CAS Number: 83846-83-7
• Molecular Weight: 545.51
• EC Number: 281-062-8
• MDL number: MFCD00084651
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278121
• NACRES: NA.77

Properties

• Assay: ≥97%
• form: solid
• color: white
• solubility: ethanol: 3 mg/mL; DMSO: 52 mg/mL (lit.)(lit.); 0.1 M HCl: 6 mg/mL (lit.)(lit.)
• storage temp.: 2-8°C
• SMILES string: O[C@H]([C@@H](O)C(O)=O)C(O)=O.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4ccccc4C3=O
• InChI: 1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
• InChI key: KMTLTEVOQLMYRS-LREBCSMRSA-N
• Gene Information: human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Description

Application

Ketanserin (+)-tartrate salt has been used:

• as a 5HT2A antagonist in Krebs-Henseleit buffer solution
• for hormonal treatment to study the effects of exogenous manipulation of different hormonal systems in interaction with parasite infection on client′s behavior
• to study the behavioural changes of incision pain rats

Biochem/physiol Actions

Ketanserin stimulates collagen synthesis and is involved in wound healing.

Selective 5-HT₂ serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves