MABN2548
Anti-CLN6 Antibody, clone N400/24
clone N400/24, from mouse
Synonym(s):
Ceroid-lipofuscinosis neuronal protein 6
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N400/24, monoclonal
species reactivity
human
packaging
antibody small pack of 25 μg
technique(s)
immunohistochemistry: suitable (paraffin)
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
target post-translational modification
unmodified
Gene Information
human ... CLN6(54982)
General description
Ceroid-lipofuscinosis neuronal protein 6 (UniProt: Q9NWW5; also known as CLN6) is encoded by the CLN6 gene (Gene ID: 54982) in human. CLN6 is a multi-pass membrane protein that is localized to endoplasmic reticulum and contributes to lysosomal function and viability of neurons. It has no homology with known proteins or functional domains, however it is highly conserved across mammalian species. Mutations in CLN6 gene have been linked to ceroid lipofuscinosis, neuronal 6 and 4A that are characterized by intracellular accumulation of autofluorescent liposomal material, seizures, dementia, visual loss, and/or cerebral atrophy. Two isoforms of CLN6 have been described that are produced by alternative splicing.
Specificity
Clone N400/24 specifically detects human Ceroid-lipofuscinosis neuronal protein 6. It does not cross-react with other CLN proteins.
Immunogen
Recombinant fragments corresponding to 54, 47, and 30 amino acids from non-helical regions from the N-terminal, internal, and C-terminal regions of human Ceroid-lipofuscinosis neuronal protein 6 (CLN6).
Application
Anti-CLN6, clone N400/24, Cat. No. MABN2548, is a highly specific mouse monoclonal antibody that targets CLN6 and has been tested for use in Immunohistochemistry (Paraffin).
Research Category
Neuroscience
Neuroscience
Quality
Evaluated by Immunohistochemistry (Paraffin) in human stomach tissue sections.
Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected CLN6 in human stomach tissue sections.
Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected CLN6 in human stomach tissue sections.
Target description
35.92 kDa calculated.
Physical form
Format: Purified
Protein G purified
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
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