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  • [Cleavage of 2-phenylpropan-1-ol and 2-phenylpropan-2-ol-glucuronide, 2 metabolites of isopropylbenzol (Cumol)].

[Cleavage of 2-phenylpropan-1-ol and 2-phenylpropan-2-ol-glucuronide, 2 metabolites of isopropylbenzol (Cumol)].

Zeitschrift fur Rechtsmedizin. Journal of legal medicine (1986-01-01)
S Goenechea, G Rücker, G Hoffmann, M Neugebauer, M Langer
ABSTRACT

The behaviour of 2-phenyl-1-propanol (I) and 2-phenyl-2-propanol (II) and their glucuronides with HCl has been investigated. While I shows a high acidic constancy, II undergoes a partial conversion into 2-phenylpropane (III) which itself yields numerous products. The glucosidic bond of glucuronide I is quantitatively split by 10.0% HCl, whereby an aglucone yield of nearly 100% is obtained. The second glucuronide behaves otherwise: the recovery of II is very low (only 40% to 45%) with HCl concentrations of 1.0%-20.0%, although with 1.0% HCl 100% of the glucuronide is hydrolysed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Phenyl-1-propanol, 97%
Sigma-Aldrich
2-Phenyl-2-propanol, 97%
Sigma-Aldrich
2-Phenyl-1-propanol, ≥97%, FG