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  • The SLC22 family with transporters of organic cations, anions and zwitterions.

The SLC22 family with transporters of organic cations, anions and zwitterions.

Molecular aspects of medicine (2013-03-20)
Hermann Koepsell
ABSTRACT

The SLC22 family contains 13 functionally characterized human plasma membrane proteins each with 12 predicted α-helical transmembrane domains. The family comprises organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). The transporters operate as (1) uniporters which mediate facilitated diffusion (OCTs, OCTNs), (2) anion exchangers (OATs), and (3) Na(+)/zwitterion cotransporters (OCTNs). They participate in small intestinal absorption and hepatic and renal excretion of drugs, xenobiotics and endogenous compounds and perform homeostatic functions in brain and heart. Important endogeneous substrates include monoamine neurotransmitters, l-carnitine, α-ketoglutarate, cAMP, cGMP, prostaglandins, and urate. It has been shown that mutations of the SLC22 genes encoding these transporters cause specific diseases like primary systemic carnitine deficiency and idiopathic renal hypouricemia and are correlated with diseases such as Crohn's disease and gout. Drug-drug interactions at individual transporters may change pharmacokinetics and toxicities of drugs.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
α-Ketoglutaric acid, ≥98.5% (NaOH, titration)
Sigma-Aldrich
α-Ketoglutaric acid, BioReagent, suitable for cell culture, suitable for insect cell culture
Sigma-Aldrich
α-Ketoglutaric acid sodium salt, BioUltra
Sigma-Aldrich
α-Ketoglutaric acid sodium salt, ≥98% (titration)
Sigma-Aldrich
α-Ketoglutaric acid potassium salt, ≥98% (enzymatic)
Sigma-Aldrich
α-Ketoglutaric acid, 99.0-101.0% (T)
Sigma-Aldrich
α-Ketoglutaric acid disodium salt dihydrate, ≥98.0% (dried material, NT)
Supelco
α-Ketoglutaric acid disodium salt hydrate, ≥95%
Sigma-Aldrich
L-Carnitine inner salt, synthetic, ≥98%
Levocarnitine, European Pharmacopoeia (EP) Reference Standard