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  • Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax.

Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax.

Carbohydrate polymers (2012-09-04)
C Cencetti, D Bellini, A Pavesio, D Senigaglia, C Passariello, A Virga, P Matricardi
ABSTRACT

Silver-loaded dressings are designed to provide the same antimicrobial activity of topical silver, with the advantages of a sustained silver release and a reduced number of dressing changes. Moreover, such type of dressing must provide a moist environment, avoiding fiber shedding, dehydration and adherence to the wound site. Here we describe the preparation of a novel silver-loaded dressing based on a Gellan/Hyaff(®) (Ge-H) non woven, treated with a polyvinyl alcohol (PVA)/borax system capable to enhance the entrapment of silver in the dressing and to modulate its release. The new hydrophilic non woven dressings show enhanced water uptake capability and slow dehydration rates. A sustained silver release is also achieved. The antibacterial activity was confirmed on Staphylococcus aureus and Pseudomonas aeruginosa.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Sodium tetraborate decahydrate, BioXtra, ≥99.5%
Sigma-Aldrich
Sodium tetraborate decahydrate, ReagentPlus®, ≥99.5%
Sigma-Aldrich
Sodium tetraborate decahydrate, ACS reagent, ≥99.5%
Sigma-Aldrich
Sodium tetraborate decahydrate, puriss., meets analytical specification of Ph. Eur., BP, NF, 99.0-103.0%
Sigma-Aldrich
Sodium tetraborate decahydrate, puriss. p.a., ACS reagent, reag. ISO, buffer substance, ≥99.5%