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  • Polysaccharide-based hydrogels: preparation, characterization, and drug interaction behaviour.

Polysaccharide-based hydrogels: preparation, characterization, and drug interaction behaviour.

Biomacromolecules (2008-03-19)
Eunice F S Vieira, Antonio R Cestari, Claudio Airoldi, Watson Loh
ABSTRACT

Oxidized alginate (ADA) and oxidized alginate blended with chitosan (ADA-Chit) were prepared in the presence of borax and CaCl 2, and their interactions with an antifolate drug, pyrimethamine (PYR), have been investigated. Tablets with a mean diameter of 1.2 +/- 0.06 cm were produced and drug interactions were performed in dimethyl sulfoxide (DMSO) using isothermal titration calorimetry (ITC). From ITC responses, the enthalpy changes of interaction PYR/materials, Delta int H, have been determined and were found to be -11.73 +/- 0.517 kJ mol (-1) for ADA and -4.86 +/- 0.156 kJ mol (-1) for ADA-Chit. The PYR encapsulation of approximately 75% was achieved for both materials, as measured by UV spectrometer.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Sodium tetraborate decahydrate, BioXtra, ≥99.5%
Sigma-Aldrich
Sodium tetraborate decahydrate, ACS reagent, ≥99.5%
Sigma-Aldrich
Sodium tetraborate decahydrate, puriss., meets analytical specification of Ph. Eur., BP, NF, 99.0-103.0%
Sigma-Aldrich
Sodium tetraborate decahydrate, ReagentPlus®, ≥99.5%
Sigma-Aldrich
Sodium tetraborate decahydrate, puriss. p.a., ACS reagent, reag. ISO, buffer substance, ≥99.5%