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D-044

Supelco

Duloxetine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Duloxetine hydrochloride solution

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About This Item

Empirical Formula (Hill Notation):
C18H20ClNOS
CAS Number:
136434-34-9
Molecular Weight:
333.88
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CNCCC(Oc1ccc2ccccc2c1)c3cccs3

InChI

1S/C18H19NOS.ClH/c1-19-11-10-17(18-7-4-12-21-18)20-16-9-8-14-5-2-3-6-15(14)13-16;/h2-9,12-13,17,19H,10-11H2,1H3;1H

InChI key

QZIJQNJKJMLFKV-UHFFFAOYSA-N

Related Categories

General description

Duloxetine, marketed in the US under the trade name Cymbalta®, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder and to alleviate pain associated with diabetic neuropathy, fibromyalgia, and osteoarthritis. This Certified Spiking Solution® is applicable for use in applications such as clinical toxicology, urine drug testing, and forensic analysis by LC-MS/MS or GC/MS.

Application


  • Duloxetine HCl in Drug Release Studies: A study evaluated the application of bicarbonate buffer dissolution testing with gentle mechanistic stress to predict bioequivalence of enteric-coated pellet formulations including Duloxetine HCl, emphasizing its importance in CNS pharmacology and pharmaceutical quality control (Ikuta et al., 2024).

  • Nanovesicle Formulation of Duloxetine: Research explored the formulation and optimization of ultra-elastic nanovesicles loaded with Duloxetine HCl, aimed at enhancing the antidepressant effect through intranasal and transdermal delivery. This approach provides insights into advanced drug delivery systems for CNS pharmacology and neurotransmitter research (Abd-Elal et al., 2023).

  • Pharmacokinetics and Pharmacodynamics: An investigation into chitosan-grafted PLGA nanoparticles aimed to boost the pharmacokinetic and pharmacodynamic effect of Duloxetine HCl using Box-Benkhen Design, contributing to the understanding of its bioavailability and therapeutic efficacy in biochemical research on antidepressants (Salem et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Cymbalta is a registered trademark of Eli Lilly and Co.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Long Ma et al.
Neural regeneration research, 16(10), 2093-2098 (2021-03-02)
After spinal cord injury, the upward conduction of the spinal cord is lost, resulting in the loss of micturition control, which manifests as detrusor sphincter dyssynergia and insufficient micturition. Studies have shown that serotonergic axons play important roles in the

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