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840030P

Avanti

06:0 PS

1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder

Synonym(s):

PS(6:0/6:0)

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About This Item

Empirical Formula (Hill Notation):
C18H33NO10PNa
CAS Number:
321862-85-5
Molecular Weight:
477.42
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840030P-10mg)
pkg of 1 × 25 mg (840030P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840030P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]

InChI

1S/C18H34NO10P.Na/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23;/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25);/q;+1/p-1/t14-,15+;/m1./s1

InChI key

OPDYVXCKOQKYDZ-LIOBNPLQSA-M

General description

Phosphatidylserine (PS) is an acidic phospholipid. Approximately 15–33 mol% of PS is present in the inner leaflet of the plasma membrane.

Application

06:0 PS may be used to study its effect on α-syn (α-synuclein) oligomerization by DA (dopamine) and as a phospholipid substrate to determine the kinetic parameters for phospholipase C by chromogenic assay. It has also been used in the preparation of phospholipid vesicles.

Biochem/physiol Actions

Phosphatidylserine (PS) participates in several signaling pathways. This membrane phospholipid controls the Akt (protein kinase B) phosphorylation process.

Packaging

5 mL Clear Glass Sealed Ampule (840030P-10mg)
5 mL Clear Glass Sealed Ampule (840030P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 223-249 (2008)
Akt-GSK3 beta Pro-survival Signaling Pathway in Cerebral Ischemic Injury
Primer on Kidney Diseases, Volume 953, 269-272 (2017)
Mingquan Guo et al.
Journal of molecular neuroscience : MN, 33(1), 67-73 (2007-09-29)
Phosphatidylserine (PS), the major acidic phospholipid class in eukaryotic biomembranes, plays an important role in various signaling pathways. We have previously demonstrated that docosahexaenoic acid (DHA, 22:6n-3) positively modulates PS biosynthesis and accumulation in neuronal cells, promoting survival. In this
Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 223-249 (2008)
Chi L L Pham et al.
Bioscience reports, 33(5) (2013-09-27)
The deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of DA (dopamine) containing neurons in the substantia nigra are two key features of PD (Parkinson's disease). α-syn is a natively unfolded protein and adopts an α-helical conformation
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Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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