QBD10198

NHS-dPEG^®₁₂-biotin

• Synonym(s): NHS-PEG Linker, Polyethylene glycol
• Empirical Formula (Hill Notation): C₄₁H₇₂N₄O₁₈S
• Molecular Weight: 941.09
• UNSPSC Code: 12161502
• PubChem Substance ID: 329823889
• NACRES: NA.22

Properties

• Assay: >90%
• form: solid or viscous liquid
• reaction suitability: reagent type: cross-linking reagent; reaction type: Biotinylations; reactivity: amine reactive
• polymer architecture: shape: linear; functionality: monofunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCCC1C2NC(NC2CS1)=O)=O)ON3C(CCC3=O)=O

Description

Features and Benefits

NHS-dPEG^®₁₂-biotin is used extensively to label molecules that contain a free amine with biotin. The single molecular weight NHS-dPEG^®₁₂-biotin has a long spacer of precise length (47.6 Å) between the biotin moiety and the labeled molecule. This dPEG^® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG^® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable