跳轉至內容
Merck
  • Mixed matrix hollow fiber membranes for removal of protein-bound toxins from human plasma.

Mixed matrix hollow fiber membranes for removal of protein-bound toxins from human plasma.

Biomaterials (2013-07-24)
Marlon S L Tijink, Maarten Wester, Griet Glorieux, Karin G F Gerritsen, Junfen Sun, Pieter C Swart, Zandrie Borneman, Matthias Wessling, Raymond Vanholder, Jaap A Joles, Dimitrios Stamatialis
摘要

In end stage renal disease (ESRD) waste solutes accumulate in body fluid. Removal of protein bound solutes using conventional renal replacement therapies is currently very poor while their accumulation is associated with adverse outcomes in ESRD. Here we investigate the application of a hollow fiber mixed matrix membrane (MMM) for removal of these toxins. The MMM hollow fiber consists of porous macro-void free polymeric inner membrane layer well attached to the activated carbon containing outer MMM layer. The new membranes have permeation properties in the ultrafiltration range. Under static conditions, they adsorb 57% p-cresylsulfate, 82% indoxyl sulfate and 94% of hippuric acid from spiked human plasma in 4 h. Under dynamic conditions, they adsorb on average 2.27 mg PCS/g membrane and 3.58 mg IS/g membrane in 4 h in diffusion experiments and 2.68 mg/g membrane PCS and 12.85 mg/g membrane IS in convection experiments. Based on the dynamic experiments we estimate that our membranes would suffice to remove the daily production of these protein bound solutes.

材料
產品編號
品牌
產品描述

Sigma-Aldrich
吲苷 钾盐
Sigma-Aldrich
马尿酸, 98%
Sigma-Aldrich
马尿酸钠 水合物, ≥99%