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Merck
  • Phase II evaluation of bisantrene in acute leukemia. A Southwest Oncology Group Study.

Phase II evaluation of bisantrene in acute leukemia. A Southwest Oncology Group Study.

American journal of clinical oncology (1989-12-01)
G M Mills, S Dahlberg, J Cowan, B A Neilan, C H Gumbart, K Hussein, C A Coltman
摘要

Twenty-nine patients with heavily pretreated acute leukemia in relapse were treated with bisantrene (maximum dose 120 mg/m2/day x 5) in a phase II study. Twenty-seven of the 29 patients were evaluable for response, receiving a total of 53 courses of treatment. There were three complete remissions (11%) lasting 27, 107, and 115 days. One brief partial remission of 43 days was also seen for a total response rate of 15%. Toxicity was mainly limited to the expected myelotoxicity with minimal nonhematologic toxicity seen. Although the complete remission rate is low, an antileukemic effect was seen in the majority of the patients treated. Sixty-one percent of the patients had at least a 50% decrease in the circulating blast count and 32% had at least a 50% decrease in the number of bone marrow blasts. We conclude that bisantrene does have an antileukemic effect, but that the optimal starting dose is not yet established.

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比生群二盐酸盐, ≥98% (HPLC)