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Merck
  • Mild arming and derivatization of natural products via an In(OTf)3-catalyzed arene iodination.

Mild arming and derivatization of natural products via an In(OTf)3-catalyzed arene iodination.

Organic letters (2010-04-15)
Cong-Ying Zhou, Jing Li, Satyamaheshwar Peddibhotla, Daniel Romo
摘要

Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)(3) at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR studies, homo- and heterodimerization of natural products, and also conjugation with reporters such as biotin via subsequent metal-mediated coupling reactions.

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Sigma-Aldrich
N-碘代琥珀酰亚胺, 95%